Endocrine Abstracts

Introduction: POEMS syndrome is a rare multisystem disorder characterized by polyneuropathy, organomegaly, endocrinopathy, monoclonal plasma-proliferative disorder and skin changes. Different endocrinopathies are found in 58-80% of patients, however, its pathophysiology remains unknown. Hypogonadism (primary and secondary) is the most common endocrinopathy (79% of patients), with other abnormalities including hyperprolactinemia (56%), primary hypothyroidism (54%), abnormal glu...

Introduction: The interaction between obesity and bone metabolism is complex and not fully understood. Historically, higher body weight was considered to be protective against osteoporosis. This association has affected clinical practice: body mass index (BMI) is one of the variables included in Fracture Risk Assessment Tool (FRAX), where a higher BMI leads to a lower fracture risk. Despite this association between bone mineral density (BMD) and body weight, it is not clear wh...

Introduction: Giant prolactinomas (diameter >4 cm) account for less than 5% of all prolactinomas and are usually associated with markedly elevated prolactin (PRL) levels. Despite their benign nature, these tumors can be invasive, potentially leading to mass effect symptoms in affected patients.Case Report: We report a case of a 40-year-old male admitted to the emergency department with a one-week history of headaches, right palpebral edema, and ptosi...

Background: Acromegaly is a rare disorder associated with excessive levels of growth hormone(GH) and insulin-like growth factor-1(IGF-1). GH/IGF-1 excess leads to morphologic craniofacial and acral changes as well as cardiometabolic complications, but the phenotypic changes and presentation differ across species.Aim: To present the resemblances and distinctive features of acromegaly in humans, cats and dogs.Methods: A literature re...

Introduction: Cancer treatment including oophorectomy, radiotherapy and chemotherapy with gonadotoxic agents may induce premature ovarian failure. Early diagnosis and treatment of ovarian failure avoids cardiovascular disorders, osteoporosis and compromised sexual health due to estrogen deficiency and also ensures growth and pubertal development in children.Aim: Raise awareness for early assessment and management of premature ovarian failure after cancer...

Introduction: Thyroid storm, a life-threatening manifestation of hyperthyroidism, presents a complex clinical challenge that demands swift and precise intervention. The heart is one of the most important target organs affected by the thyrotoxic state. Thyrotoxicosis may lead to sinus tachycardia, hypertension, tachycardiomyopathy, atrial fibrillation and heart failure.Case Presentation: A 46-year-old female presented to the emergency department with symp...

Introduction: Medullary thyroid carcinoma (MTC) arises from thyroid parafollicular C cells and accounts for <5% of thyroid cancers. Nearly 25% occur in the context of multiple endocrine neoplasia type 2 syndrome (MEN2) or familial isolated MTC.Objectives: Evaluation of clinical characteristics and evolution of patients with MTC.Methods: Retrospective analysis of clinical records of patients with MTC diagnosed from 2001 to 2023....

Introduction: Factitious thyrotoxicosis is caused by intentional and surreptitious ingestion of thyroid hormone and can be a challenge in the differential diagnosis with other pathologies.Case report: Female, 35 years old, referred to our department for suspected subacute thyroiditis after COVID-19. The patient had previous medical history of hysterectomy, bilateral oophorectomy, 2 galactophorectomies with right breast reconstruction, depressive syndrome...

Introduction: Continuous glucose monitoring systems (CGM) have revolutionized the monitoring of diabetes, allowing real-time measurement of interstitial glucose levels. Although these devices are suitable for patients on insulin therapy, they are not yet routinely used in an inpatient setting. The difficulty observed in the glycemic control of hospitalized patients under intensive insulin therapy led to the development of a protocol to study the application of CGM in these pat...

Introduction: In 2020, a group of experts proposed to change the term “non-alcoholic fatty liver disease” (NAFLD) to “metabolic-associated fatty liver disease” (MAFLD), which includes hepatic steatosis (HS) (using imaging or analytical scores) associated with overweight or obesity, type 2 diabetes (T2D), or the presence of two other metabolic disorders.Objectives: Analyse the impact of bariatric surgery on MAFLD.<p class="abstext"...